Association of magnesium depletion score with serum anti-aging protein Klotho in the middle-aged and older populations

This study provides novel evidence of an inverse association between MDS, a new valuable indicator of magnesium status, and serum Klotho levels in a large, representative sample of US adults. These findings suggest that monitoring magnesium status via MDS could help identify individuals at risk of accelerated aging, prompting interventions such as dietary adjustments or magnesium supplementation in high-risk populations. Further research is warranted to elucidate the mechanisms underlying this association and its implications for age-related diseases.