Advancing personalized diagnosis and treatment using deep learning architecture

Autoimmune disorders (AID) present significant challenges due to their complex etiologies and diverse clinical manifestations. Traditional diagnostic methods, which rely on symptom observation and biomarker detection, often lack specificity and fail to provide personalized treatment options. This study proposes ImmunoNet, a deep learning-based framework that integrates genetic, molecular, and clinical data to enhance the accuracy of autoimmune disease diagnosis and treatment. ImmunoNet leverages convolutional neural networks (CNNs) and multi-layer perceptrons (MLPs) to analyze large-scale datasets, enabling precise disease classification and personalized therapeutic treatment recommendations. The model improves interpretability through explainable AI techniques and enhances privacy via federated learning. Comparative evaluations demonstrate that ImmunoNet outperforms traditional machine learning models, achieving a 98% accuracy rate in predicting autoimmune disorders. By advancing precision medicine in immunology, this approach provides clinicians with a powerful tool for personalized diagnosis and optimized therapeutic strategies.

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Publication Details

Journal
Frontiers in Medicine
Published
2025-03-27
DOI
https://doi.org/10.3389/fmed.2025.1545528
Citations
20
Primary Topic
vaccines and immunoinformatics approaches
Type
article
Field-Weighted Citation Impact
16.12
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Advancing personalized diagnosis and treatment using deep learning architecture

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Frontiers in Medicine
vaccines and immunoinformatics approaches
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Advancing personalized diagnosis and treatment using deep learning architecture

Maqbool Khan, Aitizaz Ali, Rahat Ullah, Mohammed Naif Alatawi, Nadeem Sarwar, Hathal Salamah Alwageed, Abeer Abdullah Alsadhan
article en
20 citations

Abstract

Autoimmune disorders (AID) present significant challenges due to their complex etiologies and diverse clinical manifestations. Traditional diagnostic methods, which rely on symptom observation and biomarker detection, often lack specificity and fail to provide personalized treatment options. This study proposes ImmunoNet, a deep learning-based framework that integrates genetic, molecular, and clinical data to enhance the accuracy of autoimmune disease diagnosis and treatment. ImmunoNet leverages convolutional neural networks (CNNs) and multi-layer perceptrons (MLPs) to analyze large-scale datasets, enabling precise disease classification and personalized therapeutic treatment recommendations. The model improves interpretability through explainable AI techniques and enhances privacy via federated learning. Comparative evaluations demonstrate that ImmunoNet outperforms traditional machine learning models, achieving a 98% accuracy rate in predicting autoimmune disorders. By advancing precision medicine in immunology, this approach provides clinicians with a powerful tool for personalized diagnosis and optimized therapeutic strategies.

Frontiers in MedicineVol. 12
Pakistan Institute of Engineering and Applied Sciences (PK), Asia Pacific University of Technology & Innovation (MY), Jouf University (SA), Nanjing University of Information Science and Technology (CN), Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology (PK), Bahria University (PK), University of Tabuk (SA), Imam Abdulrahman Bin Faisal University (SA)
Good health and well-being
Openalex Percentile: Top 1%
vaccines and immunoinformatics approaches
16.12
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