Aqueous humor mediator levels as biomarkers of anti-VEGF response in age-related macular degeneration
The aqueous humor levels of the studied mediators remained stable after anti-VEGF IVIs, except for a significant decrease in VEGF-A levels in all patients. Patients with low baseline intraocular VEGF-A levels (i.e., ≤50 pg/mL) showed an intraocular inflammatory profile with elevated IL-6, PlGF, VEGF-C, IL-8 and TNFα levels. Treatment response correlated with high baseline VEGF-A levels. An interval > 8 weeks between the third and fourth anti-VEGF IVIs was associated with a pro-angiogenic/pro-inflammatory environment.
Authors
- Stéphanie Baillif
- Tanguy Pacé-Loscos (ORCID: https://orcid.org/0009-0007-8723-2507)
- Maeva Dufies
- Sacha Nahon‐Estève (ORCID: https://orcid.org/0000-0003-2274-0256)
- Gilles Pagès (ORCID: https://orcid.org/0000-0002-8466-5610)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Centre Hospitalier Universitaire de Nice (FR)
- Institut de Recherche sur le Cancer et le Vieillissement de Nice (FR)
- Hôpital Pasteur (FR)
- Centre Antoine Lacassagne (FR)
Publication Details
- Journal
- Cytokine
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1016/j.cyto.2025.156921
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche