High-performance liquid chromatography–tandem mass spectrometry for simultaneous determination of 23 antidepressants and active metabolites in human serum and its application in therapeutic drug monitoring
The results showed that a simple, fast, reliable and specific HPLC'MS/MS method was developed and validated, and all the performance characteristics of the method met the requirements, which could be used to study TDM and pharmacokinetics of the above 23 antidepressants and active metabolites.
Authors
- Junjie Wang (ORCID: https://orcid.org/0009-0003-6742-1758)
- Jinglong Wang (ORCID: https://orcid.org/0000-0002-4969-2453)
- Guofei Li (ORCID: https://orcid.org/0000-0001-6194-541X)
- Chenxiao Zhang (ORCID: https://orcid.org/0009-0000-9356-6801)
Institutions
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.3389/fphar.2025.1531496
- Citations
- 3
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 4.18