Spike specific IgG3 and nucleocapsid IgG response in serum serve as distinguishing immunological markers between SARS-CoV-2 infection and vaccination
The findings highlight RBD-specific IgG3 as well as nucleocapsid IgG as crucial markers for differentiating between vaccination and natural infection and suggest these assays have utility for longitudinal monitoring of vaccinations and for establishing SARS-CoV-2 correlates of protection.
Authors
- Ashraful Islam Khan (ORCID: https://orcid.org/0000-0003-3751-1974)
- Imam Tauheed (ORCID: https://orcid.org/0009-0003-6830-6161)
- Tahmina Shirin (ORCID: https://orcid.org/0000-0002-5061-3783)
- Fatema Khaton
- Afroza Akter (ORCID: https://orcid.org/0000-0001-8374-8556)
- Sayera Banu (ORCID: https://orcid.org/0000-0002-5121-1962)
- Fahima Chowdhury (ORCID: https://orcid.org/0000-0002-7082-0720)
- Taufiqur Rahman Bhuiyan (ORCID: https://orcid.org/0000-0003-3755-4763)
- Edward Thomas Ryan (ORCID: https://orcid.org/0009-0005-0169-394X)
- Ishtiakul Islam Khan (ORCID: https://orcid.org/0000-0001-9415-8113)
- Md. Rashedul Islam (ORCID: https://orcid.org/0000-0002-6176-6865)
- Zahid Hasan Khan (ORCID: https://orcid.org/0000-0002-8526-4165)
- Tasnuva Ahmed (ORCID: https://orcid.org/0009-0000-6774-6104)
- Marjahan Akhtar (ORCID: https://orcid.org/0000-0001-8316-9191)
- Fatima Rahman (ORCID: https://orcid.org/0009-0006-7169-7767)
- Prasanta Kumar Biswas (ORCID: https://orcid.org/0009-0008-2841-1860)
- T. Sami
Institutions
- Harvard University (US)
- International Centre for Diarrhoeal Disease Research (BD)
- Massachusetts General Hospital (US)
- Institute of Epidemiology, Disease Control and Research (BD)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1518915
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79