Glucocorticoid boluses followed by tocilizumab in giant cell arteritis patients: effects on peripheral blood monocytes and lymphocytes
GC boluses modified the relative percentages of lymphocyte and monocyte subsets and modified the expression levels of CCR2, CX3CR1, and HLA-DR in monocytes. These changes may contribute to the anti-inflammatory effects of GCs. TCZ monotherapy had more limited effects. Changes in CCR2 expression by intermediate monocytes might have a prognostic value in LVV.
Authors
- Alessandro Zerbini (ORCID: https://orcid.org/0000-0001-7378-0675)
- V Buia (ORCID: https://orcid.org/0000-0003-1333-9241)
- Ilaria Ferrigno (ORCID: https://orcid.org/0000-0002-8224-5997)
- Luigi Boiardi
- Carlo Salvarani (ORCID: https://orcid.org/0000-0001-5426-5133)
- Annibale Versari (ORCID: https://orcid.org/0000-0002-8675-2435)
- Chiara Marvisi (ORCID: https://orcid.org/0000-0001-7027-1410)
- Cecilia Catellani (ORCID: https://orcid.org/0000-0002-6354-9979)
- Stefania Croci (ORCID: https://orcid.org/0000-0002-8622-0439)
- Giulia Cassone (ORCID: https://orcid.org/0000-0002-3454-401X)
- Massimiliano Casali (ORCID: https://orcid.org/0000-0003-3832-8696)
- Mariagrazia Catanoso (ORCID: https://orcid.org/0000-0002-4155-6094)
- Rexhep Durmo
- Giulia Besutti (ORCID: https://orcid.org/0000-0001-5319-5495)
- Martina Bonacini (ORCID: https://orcid.org/0000-0002-6830-6781)
- Francesco Muratore (ORCID: https://orcid.org/0000-0003-0362-2668)
- Alessandro Rossi (ORCID: https://orcid.org/0000-0002-6719-3324)
- Lucia Spaggiari
- Gabriella Di Tommaso
Institutions
- University of Modena and Reggio Emilia (IT)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Azienda Unità Sanitaria Locale Piacenza (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1516008
- Citations
- 1
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.52