Evaluation of postvaccination reactions after simultaneous administration of vaccines against different infections

Aim - to evaluate the course of the postvaccination period after the simultaneous use of different vaccines in different combinations. Materials and methods. The study was conducted from January 2020 to October 2023. The records in the logs of post-vaccination reactions after immunization, made according to the data of routine monitoring of the child's condition after vaccination, were analyzed. Were selected 690 children for the analysis, divided into groups depending on the combination of different vaccines during the vaccination cycle and the first revaccination. Results. Most children in all study groups had a complaint-free post-vaccination period (60-94%). Although, according to the results of comparing postvaccination reactions in the case of combinations with different vaccines, differences were observed, but statistically unreliable. The simultaneous administration of vaccines against different infections in one visit was not accompanied by an increase in postvaccination reactions, but rather by a decrease. Conclusions. The number of simultaneously administered vaccines against different infections does not affect the frequency and severity of postvaccination reactions. The simultaneous administration of vaccines against different infections in one visit is not accompanied by an increase in postvaccination reactions, therefore it is justified, which contributes to the observance of optimal dose intervals and maximum protection of the child within the regulated time. The study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee of the Shupyk National University of Health of Ukraine. The consent of each patient, parent or guardian was obtained for the processing of personal data. The authors declare no conflict of interest.