Hedopeptolide, a NO Production Inhibitor from the Marine Cyanobacterium <i>Okeania</i> sp.
A novel 19-membered cyclic depsipeptide, hedopeptolide (<b>1</b>), was isolated from <i>Okeania</i> sp., a marine cyanobacterium collected in Okinawa, Japan. Its gross structure was determined by spectroscopic analyses, and the absolute configuration of the chiral centers was determined by single-crystal X-ray diffraction analysis following crystallization. Hedopeptolide (<b>1</b>) inhibited the lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.
Authors
- Kiyotake Suenaga (ORCID: https://orcid.org/0000-0001-5343-5890)
- Shunya Tojo (ORCID: https://orcid.org/0009-0003-1230-639X)
- Noriyuki Natsume
- Toshiaki Teruya (ORCID: https://orcid.org/0000-0002-7018-7734)
- Osamu Ohno (ORCID: https://orcid.org/0000-0002-8147-6857)
- Arihiro Iwasaki (ORCID: https://orcid.org/0000-0002-3775-5066)
- Taiki Niino
Institutions
- Kogakuin University (JP)
- Keio University (JP)
- University of the Ryukyus (JP)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c00095
- Citations
- 5
- Primary Topic
- Synthesis and Biological Activity
- Type
- article
- Field-Weighted Citation Impact
- 4.68