Circ-ITCH promotes the ubiquitination degradation of HOXC10 to facilitate osteogenic differentiation in disuse osteoporosis through stabilizing BRCA1 mRNA via IGF2BP2-mediated m6A modification
Circ-ITCH stabilized BRCA1 mRNA via IGF2BP2-mediated m<sup>6</sup>A modification, thereby facilitating the ubiquitination degradation of HOXC10 to promote osteogenic differentiation in DOP.
Authors
- Lemei Zhu (ORCID: https://orcid.org/0000-0003-0477-3759)
- Kunli Chen
- Lingyu Kong (ORCID: https://orcid.org/0000-0002-1216-2432)
- Yaochun Li (ORCID: https://orcid.org/0000-0002-8723-0938)
- Peng Chen (ORCID: https://orcid.org/0000-0001-8582-7661)
- Xi Li (ORCID: https://orcid.org/0000-0002-9601-5076)
- Yusheng Li (ORCID: https://orcid.org/0000-0002-3404-0807)
- Long Wang (ORCID: https://orcid.org/0000-0002-2733-7370)
- Hua Liu (ORCID: https://orcid.org/0000-0003-2034-6407)
- Da Zhong (ORCID: https://orcid.org/0000-0003-4289-6899)
- Chenggong Wang (ORCID: https://orcid.org/0000-0001-7262-2376)
- Chun‐Gu Hong
- Ke Yin
- Zhen Yin
- Jian Tian
Institutions
- Central South University (CN)
- Changsha Medical University (CN)
- Nankai University (CN)
- Xiangya Hospital Central South University (CN)
- University of South China (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1186/s12967-024-06050-5
- Citations
- 10
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 8.06
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province