The Association between Serum Magnesium Level and Microalbuminuria in Diabetic Patients Attending Sebha Diabetic and Endocrine Centre, Sebha-Libya

Background: Magnesium is one of the essential elements for various vital processes in the humanbody and has an important role in glucose metabolism. Magnesium deficiency may play a role inpoor glycemic control and the development of diabetic complications.Objective: This study aimed to investigate the potential association between magnesiumdeficiency and elevated microalbuminuria levels.Method: This study was conducted during the period from June 2023 to January 2024 at theDiabetes and Endocrinology centre in Sabha-Libya. We studied 124 diabetic patients and 44healthy individuals as controls in the Sebha Diabetic and Endocrine Centre. Blood samples werecollected for the analysis of Fasting Blood Sugar (FBS), hemoglobin A1c (HbA1C), lipid profile(Triglyceride (TG), Cholesterol (CHOL), Low –Density Lipoprotein (LDL), and High-DensityLipoprotein (HDL), Urea, Creatinine (CREA), and Magnesium (Mg) concentrations by standardmethods. The uthors also collect urine samples for microalbuminuria (MAU) and creatinine tests.Results: The research results showed that Mg2+ level was lower in DM patients (Mean±SD Mg2+mg\dl=1.75±0.22), compared to control group (Mean±SDMg2+mg\dl=1.98±0.15).and the differentwas statically significant (p=0.000), Mg2+ has shown negative correlation with FBS (r= -0.261,p=0.033), and with HbA1C (r= -0.142, p=0.003). Also there was a significantly negativecorrelation between Mg2+ and MAU(r= -0.445, p=0.000).Conclusion: In the present study we found a significantly negative correlation between serumMg2+ and MAU in diabetic group.