Integrated single-cell and bulk transcriptomic analysis identifies a novel macrophage subtype associated with poor prognosis in breast cancer
This study uncovers a previously unrecognized TAM subtype that drives poor prognosis in BC. The identification of M_Macrophage-SPP1-C1Q enhances our understanding of TAM heterogeneity within the TME and offers a novel prognostic biomarker. The Macro.RF model provides a robust tool for predicting clinical outcomes and guiding personalized treatment strategies in BC patients.
Authors
- Yushuai Yu (ORCID: https://orcid.org/0009-0002-2494-4981)
- Mingyao Huang (ORCID: https://orcid.org/0009-0004-4566-4350)
- Wei Chen (ORCID: https://orcid.org/0000-0003-3461-6658)
- Qing Wang (ORCID: https://orcid.org/0000-0002-9855-4348)
- Xiaomei Sun
- Zirong Jiang
- Liming Ruan (ORCID: https://orcid.org/0000-0001-7313-9204)
- Jun Liu (ORCID: https://orcid.org/0000-0001-7827-2354)
Institutions
- Fujian Medical University (CN)
- Ningde Normal University (CN)
- Shanghai First People's Hospital (CN)
- Fujian Provincial Hospital (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1186/s12935-025-03750-w
- Citations
- 6
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- Natural Science Foundation of Fujian Province