Radiosensitization effect of iridium (III) complex on lung cancer cells via mitochondria apoptosis pathway
This study provides robust evidence that Ir-1 is a promising and safe radiosensitizer for lung cancer therapy. Its ability to enhance radiation-induced cytotoxicity through mitochondrial dysfunction and activation of apoptotic pathways highlights its potential for clinical application.
Authors
- Shiyi Liu (ORCID: https://orcid.org/0000-0002-9920-0058)
- Yunwei Pang (ORCID: https://orcid.org/0000-0002-7312-179X)
- Qiqi Meng
- Qi Zhang (ORCID: https://orcid.org/0000-0003-2496-8844)
- Chenlan Xu
- Yangchen Cui
- Yang Jiao
- Huihui Jiang (ORCID: https://orcid.org/0000-0002-9445-3734)
- Jihua Nie
- Yan An (ORCID: https://orcid.org/0009-0004-7089-2523)
Institutions
- Soochow University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.3389/fphar.2025.1562228
- Citations
- 3
- Primary Topic
- Synthesis and Characterization of Heterocyclic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 2.81