CORRELATION OF BLOOD PRESSURE VARIABILITY AND MARKERS OF INFLAMMATION IN CHRONIC KIDNEY DISEASE PATIENTS: SYSTEMATIC REVIEW

Background: Cardiovascular complications, including blood pressure variability (BPV) is linked with chronic kidney disease (CKD). Inflammatory markers are known to be elevated in CKD and may play a role in BPV. In this systematic review our aims to study in deep the correlation between BPV and inflammatory markers in patients with CKD. Methods: Studies published from first month of 2014 to sixth month of 2024 and these studies was indexed in PubMed, Scopus, and Cochrane Library. Researches and reviews which explored the correlation between blood pressure variability and inflammatory markers in chronic kidney disease patients were selected. The data extraction and quality evaluation were carried out separately by two reviewers. Results: Among the 1375 articles reviewed, 28 had different definitions for BPV and inflammatory markers, but the majority of studies focused on systolic and diastolic BPV. These studies mostly found elevated BPV and higher IL-6 levels. Meta- analysis indicated a combined correlation coefficient of 0.42 (95% CI: 0.30-0.54) between systolic BPV and CRP. Conclusion: This review reveals a strong positive relationship between BPV and inflammatory markers in CKD patients, suggesting that inflammation could play a role in BPV fluctuations. This emphasizes the requisite for additional research to explore the methods behind this connection and identify possible therapeutic targets.