Intravenous immunoglobulin as first-line acute treatment in adults with autoimmune encephalitis caused by antibodies to NMDAR, LGI1 and CASPR2
The retrospective data give evidence that there is no difference in outcome for the use of ivMP + PE over ivMP + IVIG or vice versa in the treatment of encephalitis caused by antibodies against NMDAR, LGI1 or CASPR2. Furthermore, the specific method of plasma exchange, whether plasmapheresis or immunoadsorption, did not affect the mRS at discharge.
Authors
- Jan Lewerenz (ORCID: https://orcid.org/0000-0002-9272-529X)
- Marie Madlener (ORCID: https://orcid.org/0000-0002-6299-8238)
- Martin Lesser (ORCID: https://orcid.org/0000-0002-0318-5739)
- Makbule Şenel (ORCID: https://orcid.org/0000-0002-2737-7495)
- Hagen B. Huttner (ORCID: https://orcid.org/0000-0002-0992-8871)
- Manuel Alexander Friese (ORCID: https://orcid.org/0000-0001-6380-2420)
- Michael Nagel (ORCID: https://orcid.org/0000-0001-8436-8643)
- Tania Kümpfel (ORCID: https://orcid.org/0000-0001-7509-5268)
- Simone C. Tauber (ORCID: https://orcid.org/0000-0001-9149-3071)
- Frank Leypoldt (ORCID: https://orcid.org/0000-0002-8972-515X)
- Harald Prüß (ORCID: https://orcid.org/0000-0002-8283-7976)
- Sven Guenther Meuth (ORCID: https://orcid.org/0000-0003-2571-3501)
- Franziska Thaler
- Kurt‐Wolfram Sühs (ORCID: https://orcid.org/0000-0002-8077-481X)
- Kevin M. Rostasy (ORCID: https://orcid.org/0000-0002-2180-5321)
- Michael P. Malter (ORCID: https://orcid.org/0000-0003-2535-4553)
- Kathrin Doppler (ORCID: https://orcid.org/0000-0003-2883-0009)
- Thorsten Bartsch (ORCID: https://orcid.org/0000-0001-8387-5731)
- Nico Melzer (ORCID: https://orcid.org/0000-0002-2420-701X)
- Florian Then Bergh (ORCID: https://orcid.org/0000-0001-8604-8408)
- Carsten Finke (ORCID: https://orcid.org/0000-0002-7665-1171)
- Jonathan Wickel (ORCID: https://orcid.org/0000-0002-5854-3759)
- Christian Geis (ORCID: https://orcid.org/0000-0002-9859-581X)
- Orhan Aktas
- Andréas Moser (ORCID: https://orcid.org/0000-0003-0241-0612)
- Frank Hoffmann
- Andrea Kraft (ORCID: https://orcid.org/0009-0001-3748-1798)
- Klaus-Peter Wandinger
- Martin Stangel
- Dominica Hudasch
- Joyce Christin Rittel
Institutions
- Novartis (Switzerland) (CH)
- Witten/Herdecke University (DE)
- Universität Hamburg (DE)
- University of Cologne (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universität Ulm (DE)
- Justus-Liebig-Universität Gießen (DE)
- German Center for Neurodegenerative Diseases (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Medizinische Hochschule Hannover (DE)
- Düsseldorf University Hospital (DE)
- University Hospital Münster (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- University Hospital Schleswig-Holstein (DE)
- Universitätsklinikum Aachen (DE)
- Universitätsklinikum Würzburg (DE)
- Jena University Hospital (DE)
- Klinikum Osnabrück (DE)
- Martha-Maria Hospital (DE)
- University Hospital Cologne (DE)
- University Hospital Carl Gustav Carus (DE)
- Heinrich Heine University Düsseldorf (DE)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
- RWTH Aachen University (DE)
- Leipzig University (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1007/s00415-025-13032-0
- Citations
- 8
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 11.11
Funders
- Bundesministerium für Bildung und Forschung