Tramadol During Pregnancy: Risk of Adverse Pregnancy Outcome and Major Congenital Anomalies. A Comparative Study in the <scp>EFEMERIS</scp> Database
This study found an association between tramadol use and the risk of spontaneous pregnancy termination. We cannot conclude that there is a causal link because of a possible indication bias. No association between prescription and dispensation of tramadol during the first trimester of pregnancy and an increased risk of major congenital anomalies has been found.
Authors
- Fatiha Karam
- E Ferrer
- Laurane Delteil
- Isabelle Lacroix (ORCID: https://orcid.org/0000-0001-7344-7282)
- Anthony Caillet
Institutions
- Inserm (FR)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Agence Nationale de Sécurité du Médicament et des Produits de Santé (FR)
Publication Details
- Journal
- Pharmacoepidemiology and Drug Safety
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1002/pds.70143
- Primary Topic
- Pregnancy and Medication Impact
- Type
- article
- Field-Weighted Citation Impact
- 0.00