Comparison of clinical features between patients with and without renal involvement in IgG4-related disease

From December 2014 to February 2022, 54 patients with IgG4-RD were retrospectively enrolled. Renal involvement in IgG4-RD was observed in 55.6% of the patients. The differences of age and lacrimal gland accumulation were statistically significant (P < 0.001, and P = 0.034, respectively). Age was significantly higher in the kidney injury group. Regarding laboratory findings, basophil counts, hemoglobin levels, and serum cholinesterase level were significantly lower in patients with renal involvement (P = 0.033, P = 0.006 and P = 0.019). Erythrocyte sedimentation rate level was significantly higher in patients with renal involvement (P = 0.017). Seven (23.4%) patients in the kidney injury group relapsed during follow-up with mean recurrence time 9.86 ± 7.08 months. Early diagnosis plays a key role in patient outcomes. Female, elevated erythrocyte sedimentation rate level, and elevated complement component 4 are the risk factors for the disease relapse of IgG4-RD patients. Moreover, an effective nomogram model has been developed to predict disease relapse in patients with IgG4-RD.