Comparison of treatment outcomes between combined chemotherapy-radiation therapy (chemo-RT) and radiation therapy alone (RT) for intracranial germ cell tumors in adolescent and young adult patients (AYA)

To the best of our knowledge, we present findings on the outcomes of iGCT patients in the AYA age group. After adjusting the hazard ratio, we found no significant difference between patients who received chemotherapy and those who underwent radiotherapy alone in terms of event-free survival and overall survival. Standardized long-term term survival follow-up and supportive treatment in AYA group is needed to improve the outcome and minimize toxicity in this group. There is a need for further randomized control trials that specifically address the population of patients with AYA to improve our understanding of their potential treatment approaches.