It's Time to Stop Excluding Early Pregnancy (Losses)

Current guidelines for the care of recurrent pregnancy loss patients in New Zealand typically limit the definition to clinical pregnancies. This approach is not supported by the available evidence, which shows that very early losses are just as prognostically important as clinical losses. Clinical pregnancy is a biologically meaningless construct and is not a suitable method for determining whether a loss is 'valid' or not. The exclusion extends to clinical trials, where treatment is often not initiated until clinical pregnancy has been established. Treatment opportunities are being missed as a result. This exclusion of early pregnancy needs to stop.

Authors

Publication Details

Journal
Australian and New Zealand Journal of Obstetrics and Gynaecology
Published
2025-03-26
DOI
https://doi.org/10.1111/ajo.70033
Primary Topic
Prenatal Screening and Diagnostics
Type
article
Field-Weighted Citation Impact
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article

It's Time to Stop Excluding Early Pregnancy (Losses)

Miranda Aalderink
Australian and New Zealand Journal of Obstetrics and Gynaecology
Prenatal Screening and Diagnostics
article

It's Time to Stop Excluding Early Pregnancy (Losses)

Miranda Aalderink
article en

Abstract

Current guidelines for the care of recurrent pregnancy loss patients in New Zealand typically limit the definition to clinical pregnancies. This approach is not supported by the available evidence, which shows that very early losses are just as prognostically important as clinical losses. Clinical pregnancy is a biologically meaningless construct and is not a suitable method for determining whether a loss is 'valid' or not. The exclusion extends to clinical trials, where treatment is often not initiated until clinical pregnancy has been established. Treatment opportunities are being missed as a result. This exclusion of early pregnancy needs to stop.

Australian and New Zealand Journal of Obstetrics and GynaecologyVol. 65(6)
Good health and well-being
Openalex Percentile: Top 92%
Prenatal Screening and Diagnostics
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It's Time to Stop Excluding Early Pregnancy (Losses) — Miranda Aalderink · Australian and New Zealand Journal of Obstetrics and Gynaecology (2025) | TGRS Research Map | TGRS