ZYG11B suppresses multiple enteroviruses by triggering viral VP1 degradation
E3 ubiquitin ligases and deubiquitinases have become important topics of competition between viruses and hosts. Here, we identified CRL2<sup>ZYG11B</sup> as an E3 ubiquitin ligase complex capable of degrading structural protein VP1 of enteroviruses, making ZYG11B a broad-spectrum antiviral factor. We first proposed the inhibitory effect of ZYG11B on viruses and identified the structural domains of ZYG11B connecting substrates and CUL2, providing new targets for the design of antiviral drugs.
Authors
- Tian Li (ORCID: https://orcid.org/0000-0001-5117-7883)
- Weijing Yang (ORCID: https://orcid.org/0000-0002-9856-0385)
- Zhizhong Mi
- Zhaolong Li (ORCID: https://orcid.org/0000-0003-3795-7220)
- Wenyan Zhang (ORCID: https://orcid.org/0000-0003-4507-521X)
- Jing Chen (ORCID: https://orcid.org/0000-0003-4190-9328)
- Xing Wei
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- Institute of Virology of the Slovak Academy of Sciences (SK)
Publication Details
- Journal
- Journal of Virology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1128/jvi.00030-25
- Citations
- 2
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- National Natural Science Foundation of China
- Jilin University
- National Key Research and Development Program of China