Proton density fat fraction for diagnosis of metabolic dysfunction–associated steatotic liver disease
PDFF was the most accurate single classifier for diagnosing MASLD, MASH, and fibrotic MASH. The most accurate multivariable classification models for MASLD, MASH, and fibrotic MASH included PDFF, demonstrating the central importance of PDFF for noninvasive assessment of the MASLD spectrum.
Authors
- Thekla Oechtering (ORCID: https://orcid.org/0000-0002-1931-1912)
- David T. Harris (ORCID: https://orcid.org/0000-0001-9850-6234)
- Eduardo L. Grunvald (ORCID: https://orcid.org/0000-0001-9332-7069)
- Claude B. Sirlin (ORCID: https://orcid.org/0000-0002-6639-9072)
- Gavin Hamilton (ORCID: https://orcid.org/0000-0001-9302-5546)
- Garth R. Jacobsen
- Anne O. Lidor (ORCID: https://orcid.org/0000-0002-9911-3114)
- Sami Khoury (ORCID: https://orcid.org/0000-0002-7174-116X)
- Scott B. Reeder (ORCID: https://orcid.org/0000-0003-4728-8171)
- Yesenia Covarrubias
- Michael S. Middleton (ORCID: https://orcid.org/0000-0002-4247-1287)
- Lael Ceriani (ORCID: https://orcid.org/0000-0003-4427-4161)
- James Goodman (ORCID: https://orcid.org/0000-0002-1659-7644)
- Rashmi Agni (ORCID: https://orcid.org/0000-0001-7803-4647)
- Luke M. Funk (ORCID: https://orcid.org/0000-0003-4475-304X)
- Danielle Batakis
- Vitor F. Martins (ORCID: https://orcid.org/0000-0002-9060-1314)
- Tanya Wolfson
- Nikolaos Panagiotopoulos (ORCID: https://orcid.org/0000-0002-0670-2754)
- Anthony Gamst
- Santiago Horgan
- Ryan Sappenfield
Institutions
- University of Wisconsin–Madison (US)
- Pfizer (United States) (US)
- San Diego Supercomputer Center (US)
- University of California San Diego (US)
- William S. Middleton Memorial Veterans Hospital (US)
Publication Details
- Journal
- Hepatology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1097/hep.0000000000001318
- Citations
- 8
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 10.83