Protective effect of roflumilast on cyclophosphamide-induced ovarian toxicity in rats: role of SIRT1/Nrf2/nF-ĸB pathway
It can be concluded that RFL (0.5 and 1 mg/kg) protected rats against CP-induced ovarian toxicity <i>via</i> altering the SIRT1/Nrf2/NF-ĸB pathway, ameliorating histopathological changes in addition to its anti-apoptotic effect.
Authors
- Marwa S. Khattab (ORCID: https://orcid.org/0000-0002-8068-6094)
- Marawan A. Elbaset
- Hadir Farouk
- Salma A. El‐Marasy (ORCID: https://orcid.org/0000-0002-8730-0297)
Institutions
- Cairo University (EG)
- National Research Centre (EG)
- Indiana University (US)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1080/08923973.2025.2482804
- Citations
- 1
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 1.88