Regulating islet stress responses through CD47 activation
Our study provides key insights into the essential role of CD47 as a novel regulator of islet dysfunction, regulating cytoprotective responses to stress. CD47 may contribute to beta cell damage during the development of diabetes and failure of islet transplant function. Therefore, limiting CD47 activation may be a potential therapeutic tool in conditions where islet function is inadequate.
Authors
- Sally Coulter
- Kedar Ghimire (ORCID: https://orcid.org/0000-0002-4672-5256)
- Atharva Kale (ORCID: https://orcid.org/0000-0002-2665-5836)
- Ellis Patrick (ORCID: https://orcid.org/0000-0002-5253-4747)
- Harry Robertson (ORCID: https://orcid.org/0000-0001-9203-3894)
- Paulomi Mehta
- Natasha M. Rogers (ORCID: https://orcid.org/0000-0003-2456-9544)
- Vanessa Cheng
- Sohel M. Julovi (ORCID: https://orcid.org/0000-0003-0834-2366)
- Mirna Azar
Institutions
- The University of Sydney (AU)
- Westmead Hospital (AU)
- Westmead Institute for Medical Research (AU)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1007/s00125-025-06409-3
- Citations
- 5
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 10.03
Funders
- Diabetes Australia Research Trust
- Ramaciotti Foundations
- University of Sydney
- National Health and Medical Research Council