The Relationship Between Chronic Postoperative Pain and Circulating Inflammatory Biomarkers (CC-Chemokine Ligand 5, Adiponectin, and Resistin) After Fracture-Related Surgery in Pain Chronification
Our explorative cytokine analysis uncovered an imbalance in serum cytokines and chemokines during the chronification process in patients who developed CPSP 1 year after surgically treated fractures. In particular, adiponectin and resistin were noted to be novel biomarkers for CPSP development. These data provide preliminary insight into a potential unexplored crosstalk between chronic postoperative pain and adipocytokines in the chronification of CPSP, which remains to be further analyzed.
Authors
- Christine H. Meyer‐Frießem (ORCID: https://orcid.org/0000-0001-8743-2065)
- Alexander Schramm (ORCID: https://orcid.org/0000-0001-7670-7529)
- Jana Aulenkamp (ORCID: https://orcid.org/0000-0001-6075-1824)
- Wiebke Hansen (ORCID: https://orcid.org/0000-0002-6020-0886)
- Sebastian Oeck (ORCID: https://orcid.org/0000-0001-9695-8771)
- Peter Zahn (ORCID: https://orcid.org/0000-0003-4756-5239)
- Nathalie M. Malewicz-Oeck
- Claudia Scheffzük
Institutions
- Essen University Hospital (DE)
- BG University Hospital Bergmannsheil Bochum (DE)
- University of Duisburg-Essen (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1213/ane.0000000000007504
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00