Immunotherapy with low-dose IL-2 attenuates vascular injury in mice with diabetic and neovascular retinopathy by restoring the balance between Foxp3+ Tregs and CD8+ T cells
This study highlights the therapeutic potential of low-dose IL-2 to reduce retinal inflammation and severe vascular injury by boosting Tregs and reducing CD8<sup>+</sup> T cells and inflammatory factors.
Authors
- Varaporn Suphapimol (ORCID: https://orcid.org/0000-0001-9581-803X)
- Abhirup Jayasimhan
- Jennifer L. Wilkinson‐Berka (ORCID: https://orcid.org/0000-0003-3512-4030)
- Devy Deliyanti (ORCID: https://orcid.org/0000-0002-0390-3454)
- Amit Joglekar
Institutions
- The University of Melbourne (AU)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1007/s00125-025-06412-8
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.37
Funders
- Juvenile Diabetes Research Foundation International
- University of Melbourne
- National Health and Medical Research Council