The Role of BMP2/4 in Intestinal Ischemia‐Reperfusion Injury: Bridging Smad1/5 and Notch Pathways via Smad6
The findings indicate that BMP2/4 exacerbate intestinal I/R injury through the Smad1/5 pathway, promoting mucosal barrier breakdown and inflammation. The Notch pathway appears to counteract these effects, offering potential therapeutic targets. Further research may focus on developing strategies to modulate these pathways to improve clinical outcomes in intestinal I/R injury.
Authors
- Binyu Luo
- Yixing Ren (ORCID: https://orcid.org/0000-0001-5227-9064)
- Long Qin
- Xiangyu Kong (ORCID: https://orcid.org/0000-0002-7765-2643)
- Qin Zhang (ORCID: https://orcid.org/0000-0002-6565-190X)
- KeWei Song (ORCID: https://orcid.org/0000-0002-0761-9741)
- Zhenghang Yu
Institutions
- North Sichuan Medical University (CN)
- Tianjin University (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
- Nanchong Central Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Gastroenterology and Hepatology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1111/jgh.16944
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00