Volumetric Absorptive Microsampling Combined with Mass Spectrometry to Support Pharmacokinetically-Guided Precision Dosing of Mycophenolate Mofetil in Pediatric Lupus Nephritis Patients
The plasma pharmacokinetics of MMF metabolites can be reliably estimated from concentrations in capillary blood using VAMS devices and only 3 timed collections. Sampling whole blood by finger-prick, a less invasive approach for patients, coupled with the specificity of LC-MS/MS can be accurately used as an alternative to plasma sampling to establish the optimal dosing regimen of MMF for patients with SLE based on dried blood samples.
Authors
- Xueheng Zhao (ORCID: https://orcid.org/0000-0002-4156-3294)
- Tomoyuki Mizuno (ORCID: https://orcid.org/0000-0002-8471-9826)
- Junfang Zhao (ORCID: https://orcid.org/0000-0003-1777-5665)
- Hermine I. Brunner (ORCID: https://orcid.org/0000-0001-9478-2987)
- Prasad Devarajan (ORCID: https://orcid.org/0000-0002-7847-8552)
- Kei Irie (ORCID: https://orcid.org/0000-0002-0820-1208)
- Kenneth D R Setchell
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- The Journal of Applied Laboratory Medicine
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1093/jalm/jfaf022
- Citations
- 2
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.97