Alterations of the microenvironment of hepatocellular carcinoma in different unfolded protein response activity states
HCC with high UPR activity had lower Stromal scores and worse prognosis. Down-regulated genes CLEC3B, RAMP3, GPR182 and DNASE1L3 may play an important regulatory role in the modification of microenvironment of HCC with high UPR activity.
Authors
- Yao Wang (ORCID: https://orcid.org/0000-0002-5296-6312)
- Wan Jian Gu
- Xiao Fei Zhu
- Gui Hong Zhang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1007/s12672-025-02164-4
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00