Identification of m6A-modified gene signatures in lung adenocarcinoma tumorigenesis and their potential role in drug resistance
56 m<sup>6</sup>A-modified gene signatures for LUAD tumorigenesis were obtained from Pearson correlation analysis between mRNA-seq and m<sup>6</sup>A-seq data, along with LASSO and WGCNA analysis. Among them, AKAP9, PLXNB2, BRPF3, HPS4, EXOC7 and KLF6 play a crucial role in LUAD tumorigenesis in an m<sup>6</sup>A modification-dependent manner.
Authors
- Siyuan Xin (ORCID: https://orcid.org/0000-0001-7058-5460)
- Qiang Ma (ORCID: https://orcid.org/0000-0003-4841-5005)
- Guojun Zhang (ORCID: https://orcid.org/0000-0001-8650-0847)
- Yukun Wang (ORCID: https://orcid.org/0000-0003-1574-6254)
- Xiaomin Han (ORCID: https://orcid.org/0009-0008-9425-2810)
- Ruyi Chang
- Ruilong Wang (ORCID: https://orcid.org/0009-0002-9369-0284)
Institutions
- Southern University of Science and Technology (CN)
- Baotou Medical College (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1007/s12672-025-02106-0
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81