Cerebellar dysfunction in frontotemporal dementia: intra-cerebellar pathology and cerebellar network degeneration
Our analyses capture significant cerebro-cerebellar disconnection in frontotemporal dementia. Corticospinal tract and motor cortex degeneration can be readily detected in non-ALS phenotypes. Intra-cerebellar pathology, coupled with the degeneration of cerebellar projections and the ensuing dysfunction of cerebro-cerebellar networks likely contribute to phenotype-defining clinical profiles in frontotemporal dementia. Infratentorial disease burden and cerebellar network dysfunction should, therefore, be carefully considered in FTD, and phenotype-defining neuropsychological profiles should not be solely attributed to supratentorial degeneration.
Authors
- Bernard L. Schneider (ORCID: https://orcid.org/0000-0001-5485-8748)
- Cédric Raoul (ORCID: https://orcid.org/0000-0003-0561-6851)
- Marlene Tahedl (ORCID: https://orcid.org/0000-0003-1762-4824)
- Fabrice Ango (ORCID: https://orcid.org/0000-0002-5548-209X)
- Orla M. Hardiman (ORCID: https://orcid.org/0000-0003-2610-1291)
- Mary C. McKenna (ORCID: https://orcid.org/0000-0002-5236-3853)
- Siobhán Hutchinson (ORCID: https://orcid.org/0000-0002-6624-4142)
- Peter Bede (ORCID: https://orcid.org/0000-0003-0492-4772)
- Jana Kleinerová (ORCID: https://orcid.org/0000-0001-8679-8516)
- Ee Ling Tan
- Angela Garcia-Gallardo
- Pierre‐François Pradat
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Montpellier (FR)
- Trinity College Dublin (IE)
- Sorbonne Université (FR)
- Laboratoire d’Imagerie Biomédicale (FR)
- Pitié-Salpêtrière Hospital (FR)
- Institute for Neurosciences of Montpellier (FR)
- St. James's Hospital (IE)
- École Polytechnique Fédérale de Lausanne (CH)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1007/s00415-025-13046-8
- Citations
- 3
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Health Research Board
- EU Joint Programme – Neurodegenerative Disease Research
- Irish Research eLibrary
- Science Foundation Ireland
- Agence Nationale de la Recherche