DNA methylation-regulated HLA-C expression modulates immune responses and metabolic alterations to influence prognosis in mesothelioma
HLA-C, regulated by DNA methylation, plays a central role in mesothelioma prognosis by modulating immune responses, inflammatory cytokines, blood cell populations, and metabolic processes within the TME. Our findings suggest that HLA-C could serve as both a prognostic biomarker and a potential therapeutic target for mesothelioma, offering new insights into the molecular mechanisms driving this aggressive cancer.
Authors
- Yue Guo (ORCID: https://orcid.org/0000-0002-2335-8465)
- Jun Ming (ORCID: https://orcid.org/0000-0002-2949-6199)
- Liang Yu (ORCID: https://orcid.org/0000-0001-7044-7391)
- Huilin Zhang
- Zhenying Guo
Institutions
- Hangzhou Normal University (CN)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1007/s00262-025-04012-4
- Citations
- 2
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China