Hit to lead optimization of carbothioate derivatives as novel succinate dehydrogenase inhibitors using a multistep virtual screening approach
The identified optimal carbothioate compound A12 served as a potent lead compound for further structural optimization as potential agricultural SDHI fungicides. © 2025 Society of Chemical Industry.
Authors
- Jiagao Cheng (ORCID: https://orcid.org/0000-0001-5355-4566)
- Cong Wang (ORCID: https://orcid.org/0000-0003-0916-7803)
- Cong Zhou (ORCID: https://orcid.org/0000-0002-0627-4593)
- Xujuan Sun
- Xuhong Qian (ORCID: https://orcid.org/0000-0003-0394-1968)
- Zhong Li (ORCID: https://orcid.org/0000-0001-6665-5040)
- Zhiping Xu (ORCID: https://orcid.org/0000-0002-8297-5658)
- Xiaoyong Xu (ORCID: https://orcid.org/0000-0003-3481-3977)
- Liangliang Cheng (ORCID: https://orcid.org/0009-0009-8274-2721)
Institutions
- East China University of Science and Technology (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Pest Management Science
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1002/ps.8795
- Citations
- 2
- Primary Topic
- Fungal Plant Pathogen Control
- Type
- article
- Field-Weighted Citation Impact
- 6.05
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China