The time course of alpha 2-plasmin inhibitor and plasmin-alpha 2-plasmin inhibitor complex levels in patients with traumatic brain injury
These findings suggest that plasmin was activated and fibrinolysis enhanced immediately after injury in most patients, while in a subset of patients, hematoma expansion due to the suppression of fibrinolytic inhibition by α2-PI negatively affected the outcome.
Authors
- Shoji Yokobori (ORCID: https://orcid.org/0000-0002-7409-704X)
- Yu Fujiki
- Yasutaka Naoe (ORCID: https://orcid.org/0000-0002-9170-0605)
- Yutaka Igarashi (ORCID: https://orcid.org/0000-0002-4305-2850)
- Tetsuro Sekine (ORCID: https://orcid.org/0000-0003-1547-6696)
- Takahiro Kanaya
- Ryuta Nakae (ORCID: https://orcid.org/0000-0003-1820-2463)
- Suzuki Go
- Yasuhiro Takayama
- Hiroyuki Yokota
Institutions
- Nippon Medical School Musashi Kosugi Hospital (JP)
- Noguchi Hospital (JP)
- Nippon Medical School Hospital (JP)
- Nippon Sport Science University (JP)
- Nippon Medical School (JP)
Publication Details
- Journal
- Acta Neurochirurgica
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1007/s00701-025-06496-6
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 0.00