Identical Seeding Characteristics and Cryo‐EM Filament Structures in FTLD‐Synuclein and Typical Multiple System Atrophy
FTD/CBS is rarely associated with MSA pathology. The cell seeding characteristics and cryo-EM findings support the classification of FTLD-synuclein as a subtype of MSA, differentiating it from genetic synucleinopathies, such as those with SNCA variants G51D and A53E, which have neuropathological features overlapping with MSA and Lewy body diseases. These cases expand the clinicopathological spectrum of MSA and FTLD and have implications for our understanding of selective neuronal vulnerability in MSA and the interpretation of α-synuclein biomarker studies.
Authors
- Catarina Franco (ORCID: https://orcid.org/0000-0003-2288-1518)
- Thomas T. Warner (ORCID: https://orcid.org/0000-0001-6195-6995)
- Viorica Chelban (ORCID: https://orcid.org/0000-0002-5817-6290)
- Sew‐Yeu Peak‐Chew (ORCID: https://orcid.org/0000-0002-7602-6384)
- Michel Goedert (ORCID: https://orcid.org/0000-0002-5214-7886)
- Sarah Wrigley (ORCID: https://orcid.org/0009-0006-9274-6409)
- Amanda L. Woerman (ORCID: https://orcid.org/0000-0003-4029-1968)
- Patrick W. Cullinane (ORCID: https://orcid.org/0000-0002-4360-2680)
- Sjors H. W. Scheres (ORCID: https://orcid.org/0000-0002-0462-6540)
- Janice L. Holton (ORCID: https://orcid.org/0000-0002-3882-5249)
- Kirsten Ebanks
- Zane Jaunmuktane (ORCID: https://orcid.org/0000-0001-7738-8881)
- Henry Houlden (ORCID: https://orcid.org/0000-0002-2866-7777)
- Yee Yen Goh
- Eduardo De Pablo‐Fernández (ORCID: https://orcid.org/0000-0003-2834-2515)
- Toby J Curless (ORCID: https://orcid.org/0000-0002-3277-7813)
- Yang Yang (ORCID: https://orcid.org/0000-0001-8912-7240)
Institutions
- Van Andel Institute (US)
- University College London Hospitals NHS Foundation Trust (GB)
- MRC Laboratory of Molecular Biology (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Medical Research Council (GB)
- Colorado State University (US)
Publication Details
- Journal
- Neuropathology and Applied Neurobiology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1111/nan.70013
- Citations
- 5
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.95