Topical Administration of Novel FKBP12 Ligand MP-004 Improves Retinal Function and Structure in Retinitis Pigmentosa Models
MP-004 shows promise as a therapeutic agent for RP, preserving retinal structure and function, likely through modulation of the FKBP12.6/RyR2 interaction. Further studies are needed to explore its pharmacokinetics and efficacy in other IRD models.
Authors
- Jose Ignacio Miranda (ORCID: https://orcid.org/0000-0002-7646-6857)
- Ainara Vallejo‐Illarramendi (ORCID: https://orcid.org/0000-0002-2409-8263)
- Pedro de la Villa (ORCID: https://orcid.org/0000-0001-9856-6616)
- Klaudia González-Imaz (ORCID: https://orcid.org/0000-0001-9057-0864)
- Leire Escudero-Arrarás (ORCID: https://orcid.org/0000-0002-4348-3271)
- J. M. Aizpurua (ORCID: https://orcid.org/0000-0002-1053-5776)
- Araceli Lara-López (ORCID: https://orcid.org/0000-0002-7216-9273)
- Javier Ruiz‐Ederra (ORCID: https://orcid.org/0000-0001-8486-8592)
- Santiago Milla‐Navarro (ORCID: https://orcid.org/0000-0002-6947-5034)
- María Rodríguez-Hidalgo (ORCID: https://orcid.org/0000-0001-6464-9245)
- Maialen Sagartzazu‐Aizpurua (ORCID: https://orcid.org/0000-0003-3711-9884)
- Adolfo López de Munaín
- Miren Sarasola-Gastesi
Institutions
- University of the Basque Country (ES)
- Universidad de Alcalá (ES)
- Instituto de Salud Carlos III (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Biogipuzkoa Health Research Institute (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1167/iovs.66.3.56
- Citations
- 2
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Rush University
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Eusko Jaurlaritza
- Euskal Herriko Unibertsitatea
- Universidad de Alcalá
- Agencia Estatal de Investigación