Predictive Markers for Sustained Viral Suppression on Dual Broadly Neutralizing Antibodies During Antiretroviral Treatment Interruption in Children
At the start of bNAb-only treatment, negative qualitative DNA, and especially negative/negative DNA and EIA, have potential to predict maintenance of viral suppression among children on dual bNAbs. HIV RNA target detection below the assay limit did not prove to be a clinically useful biomarker in the visits preceding failure.
Authors
- Corretah Boleo
- Kenneth Maswabi (ORCID: https://orcid.org/0000-0002-7944-4637)
- Roger Shapiro (ORCID: https://orcid.org/0000-0002-4832-6275)
- Shahin Lockman (ORCID: https://orcid.org/0000-0002-5384-9716)
- Oganne Batlang (ORCID: https://orcid.org/0000-0003-1186-2979)
- Maureen Sakoi (ORCID: https://orcid.org/0009-0008-5222-7756)
- Comfort Maphorisa
- Daniel R. Kuritzkes (ORCID: https://orcid.org/0000-0001-6196-5883)
- Bryan S Nelson (ORCID: https://orcid.org/0000-0002-4964-067X)
- Kathleen M. Powis (ORCID: https://orcid.org/0000-0002-4478-4471)
- Gbolahan Ajibola (ORCID: https://orcid.org/0000-0002-5408-4823)
- Sikhulile M. Moyo (ORCID: https://orcid.org/0000-0003-3821-4592)
- Jaspreet Banga (ORCID: https://orcid.org/0000-0002-1479-3721)
- Mathias Litcherfeld
- Michael D. Hughes (ORCID: https://orcid.org/0000-0001-8562-2316)
- Joseph Makhema
- Terence Mohammed
- Molly Pretorius Holme
Institutions
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Ragon Institute of MGH, MIT and Harvard (US)
- Massachusetts General Hospital (US)
- Cancer Research And Biostatistics (US)
- Botswana Harvard AIDS Institute Partnership (BW)
Publication Details
- Journal
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1097/qai.0000000000003663
- Citations
- 1
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.04