mNGS technique was used to analyze the microbiome structure of intervertebral disc tissue in 99 patients with degenerative disc disease
This study proves that hypotoxic infection may be involved in the degeneration of intervertebral disc, and the bacterial species that cause this occult infection may be more abundant than previously thought. In addition, there was a significant correlation between the biome structure of these bacteria and clinical indicators. The hypothesis of the cause of this insidious infection has the potential to change the way the disease is treated.
Authors
- Xiaobing Jiang (ORCID: https://orcid.org/0000-0002-8009-0282)
- Yanchi Gan
- Gengyang Shen
- Hui Ren
- Huiwen Liu (ORCID: https://orcid.org/0000-0001-5424-2628)
- Jingjing Tang (ORCID: https://orcid.org/0000-0002-4339-4789)
- Bowen He (ORCID: https://orcid.org/0000-0001-7794-2520)
- Bin Xie (ORCID: https://orcid.org/0000-0003-3878-3074)
- Hang Zhuo
- Hao Liu (ORCID: https://orcid.org/0009-0004-2137-0892)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- European Spine Journal
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1007/s00586-025-08778-0
- Citations
- 3
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 4.41