Predictors of neoplastic progression in gastroesophageal lesions indefinite for dysplasia
IND is a challenging diagnosis for pathologists and implies an increased risk for neoplasia, especially in BE patients, without providing definitive information for patient management. This study highlights that neoplastic progression of IND lesions is primarily associated with HIM type. For BE-IND, interval endoscopy significantly reduces progression risk, while in G-IND, OLGA staging (III-IV) is a strong predictor of progression. These findings emphasise the importance of identifying HIM and using OLGA staging in G-IND for better risk stratification and follow-up strategies.
Authors
- Francesca Galuppini (ORCID: https://orcid.org/0000-0002-3245-2322)
- Valentina Angerilli (ORCID: https://orcid.org/0000-0002-9799-9257)
- Paola Parente (ORCID: https://orcid.org/0000-0003-0591-6723)
- Angelo Paolo Dei Tos (ORCID: https://orcid.org/0000-0002-1228-8940)
- Stefano Brignola
- Matteo Fassan (ORCID: https://orcid.org/0000-0001-6515-5482)
- Alberto Fantin (ORCID: https://orcid.org/0000-0002-7206-9117)
- Stefano Realdon (ORCID: https://orcid.org/0000-0001-6843-7637)
- Jessica Gasparello (ORCID: https://orcid.org/0000-0001-8557-0739)
- Gianluca Businello (ORCID: https://orcid.org/0000-0002-0045-9140)
- Edoardo Vincenzo Savarino (ORCID: https://orcid.org/0000-0002-3187-2894)
- Gianmaria Pennelli (ORCID: https://orcid.org/0000-0003-0210-165X)
- Beatrice Filippin
Institutions
- University of Padua (IT)
- Casa Sollievo della Sofferenza (IT)
- AULSS 2 Marca Trevigiana (IT)
- Istituto Oncologico Veneto (IT)
- Centro di Riferimento Oncologico (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Histopathology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1111/his.15449
- Citations
- 1
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01