Microbial translocation and gut damage is associated with hepatic fibrosis but not steatosis in women with and without HIV
Higher KT ratio, sCD14, and sCD163 were associated with increased hepatic fibrosis but not steatosis. In fact, higher KT ratio and sCD14 were associated with decreased steatosis. This suggests that microbial translocation and gut damage may contribute to the pathogenesis of fibrosis in WWH in a mechanism unrelated to increased steatosis.
Authors
- Phyllis C. Tien
- Michelle Floris-Moore (ORCID: https://orcid.org/0009-0007-9515-2857)
- Anjali Sharma
- Howard Minkoff (ORCID: https://orcid.org/0000-0002-7800-7195)
- Ani A. Kardashian (ORCID: https://orcid.org/0000-0002-0068-0099)
- Mark H. Kuniholm (ORCID: https://orcid.org/0000-0002-0173-9806)
- Michael Plankey (ORCID: https://orcid.org/0000-0003-4554-7483)
- Jennifer C. Price (ORCID: https://orcid.org/0000-0002-3825-5696)
- Audrey L. French (ORCID: https://orcid.org/0000-0002-9776-8934)
- Deborah J. Konkle‐Parker (ORCID: https://orcid.org/0000-0002-3319-8442)
- Ighovwerha Ofotokun (ORCID: https://orcid.org/0000-0003-2735-1903)
- Margaret A. Fischl (ORCID: https://orcid.org/0000-0001-9241-5390)
- Maria Duarte (ORCID: https://orcid.org/0000-0001-5906-7507)
- Yifei Ma (ORCID: https://orcid.org/0000-0003-3326-0098)
- Peter W. Hunt (ORCID: https://orcid.org/0000-0002-4571-4870)
- Elizabeth Topper
Institutions
- Albany State University (US)
- University of North Carolina at Chapel Hill (US)
- University of Southern California (US)
- Albert Einstein College of Medicine (US)
- San Francisco VA Medical Center (US)
- State University of New York (US)
- Johns Hopkins University (US)
- University of Miami (US)
- Emory University (US)
- University of California, San Francisco (US)
- SUNY Downstate Health Sciences University (US)
- Georgetown University (US)
- Georgetown University Medical Center (US)
- John H. Stroger, Jr. Hospital of Cook County (US)
- University of Mississippi Medical Center (US)
- University at Albany, State University of New York (US)
- University of San Francisco (US)
Publication Details
- Journal
- AIDS
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1097/qad.0000000000004189
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06