Photoredox-catalyzed three-component alkylation of glycine derivatives and peptides <i>via</i> a site-selective 1,5-hydrogen atom transfer cascade
We report a visible-light-mediated three-component reaction via 1,5-HAT combined with site-selective remote C(sp 3 )–H cross-coupling reactions of alkenes with alkyl radicals for the α-C(sp 3 )–H alkylation of glycine derivatives and peptides.
Authors
- Qingyun Gu
- Li Guo (ORCID: https://orcid.org/0000-0003-3821-4058)
- Liulin Jiao
- Yong Wu (ORCID: https://orcid.org/0000-0003-0719-4963)
- Ting Yuan (ORCID: https://orcid.org/0000-0001-6990-2887)
- Jinyu Hou
- Jian Chen (ORCID: https://orcid.org/0000-0001-5128-8567)
- Zhongzhen Yang (ORCID: https://orcid.org/0000-0003-3402-0088)
- Xue Zhang (ORCID: https://orcid.org/0000-0002-1243-475X)
- Hongying Fan
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5qo00294j
- Citations
- 4
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 3.22