AAV9-cBIN1 gene therapy rescues chronic heart failure due to ischemic cardiomyopathy in a canine model
Chronic HF from ischemic cardiomyopathy can be successfully treated with low dose AAV9-cBIN1 gene therapy. This study indicates that myocardial specific therapy can dramatically reverse HF progression.
Authors
- Jennifer R Hunter
- Robin M. Shaw (ORCID: https://orcid.org/0000-0001-7429-6092)
- Joseph A. Palatinus (ORCID: https://orcid.org/0000-0002-6424-0105)
- Craig H. Selzman (ORCID: https://orcid.org/0000-0001-9218-4764)
- Mónica P. Revelo (ORCID: https://orcid.org/0000-0002-5746-408X)
- Annie M. Hirahara (ORCID: https://orcid.org/0000-0003-4113-3929)
- Anand Athavale (ORCID: https://orcid.org/0000-0002-6225-6568)
- Yuki Ishidoya (ORCID: https://orcid.org/0000-0003-2825-8479)
- Derek J. Dosdall (ORCID: https://orcid.org/0000-0001-5059-6824)
- TingTing Hong (ORCID: https://orcid.org/0000-0002-0243-5046)
- Ravi Ranjan (ORCID: https://orcid.org/0000-0002-3321-2435)
- Emmanuel Offei
- Douglas Smego (ORCID: https://orcid.org/0000-0001-8790-2653)
- Pia Balmaceda
- Jing Li (ORCID: https://orcid.org/0000-0003-4613-260X)
- Martha S. Ruiz Castillo
- Muhammad S. Khan (ORCID: https://orcid.org/0000-0002-6232-2633)
Institutions
- University of Utah (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1038/s43856-025-00787-w
- Citations
- 11
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 15.27
Funders
- American Heart Association
- Nora Eccles Treadwell Foundation
- National Heart, Lung, and Blood Institute