The relationship between obesity paradox and C-reactive protein in patients with st-segment-elevation myocardial infarctions

Aims: Inflammation plays a very important role in the pathogenesis of coronary artery disease (CAD) and its prognosis. Especially; C-reactive protein (CRP) is associated with poor prognosis in patients with CAD. In this study, the relationship between CRP levels and BMI was investigated in patients who underwent primary coronary intervention (PCI) due to ST-segment elevation myocardial infarction (STEMI). Methods: Between January 2015 and February 2016, 132 patients who underwent primary coronary intervention due to acute STEMI were included in the retrospective study. Patients were classified into two groups: (Group 1:BMI<25kg/m2 n:27 and BMI>35 kg/m2 n:9, total:36 patients; Group2: BMI>25 and BMI<30 kg/m2 n:58 and BMI>30 and BMI<35 kg/m2 n:38, total 96 patients). Class 2,3 obese patients and normal weight patients constituted Group 1 where as pre-obese and class 1 obese patients were included in Group2. The patients are grouped in this way because the prognosis of the first group is worse in obesity paradox studies. Results: CRP was found to be significantly lower in STEMI patients with BMI>25 and BMI<35. Whereas it was significantly higher in STEMI patients with BMI>25 and BMI<35. Conclusion: In this study, the relationship between CRP levels and BMI was investigated in patients who underwent primary coronary intervention (PCI) due to ST elevation myocardial infarction (STEMI). The reasons for the better prognosis of mildly overweight and class 1 obese patients with STEMI diagnosis may be the low values of CRP which has many effects on atherosclerotic plaque formation.