A practical one-pot synthesis of dehydroalanine esters
A practical one-pot synthesis of various dehydroalanine esters was realized <i>via</i> a Cs<sub>2</sub>CO<sub>3</sub>-mediated simultaneous esterification/elimination process, starting from commercially available N-protected serines and various haloalkanes. This protocol provided easy access to structurally diverse dehydroalanine-based building blocks, which were successfully applied to construct more complex dehydroalanine derived molecules.
Authors
- Minyue Zhang (ORCID: https://orcid.org/0000-0002-4428-2500)
- Mengxiao Zhu (ORCID: https://orcid.org/0000-0001-6780-7763)
- Lili Yang (ORCID: https://orcid.org/0000-0003-4274-4617)
- Qingyuan Shi
- Dongyin Chen (ORCID: https://orcid.org/0000-0002-7978-7429)
- Xiaoming Zha
- Fei Li (ORCID: https://orcid.org/0000-0002-7930-5485)
- Sun Pingping
- Changying Xing
- Dong Xu (ORCID: https://orcid.org/0000-0001-5432-6012)
- Hongliang He (ORCID: https://orcid.org/0000-0002-6099-4356)
- Zhenchu Liang
Institutions
- Soochow University (CN)
- Huaian First People’s Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra00035a
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China