СHANGES IN CYTOKINE PROFILE IN OSTEOPATHIC NON-DRUG TREATMENT OF TENSION HEADACHE

Connection of the publication with planned research works.The work was performed within the framework of the research work of Kharkiv National Medical University, "Dynamics of cognitive and psychoemotional disorders in patients with demyelinating diseases under chronic stress", state registration number 0123U104329. Introduction.Headache caused by muscle dysfunction (tension headache, TH) is the second most common disorder in the world [1].Dysfunction of the muscles of the neck and shoulder girdle often causes headaches, which are caused not only by mechanical tension, but also by inflammatory processes in the tissues.A decrease in blood supply to the brain is accompanied by the development of an inflammatory reaction (IL-6).In such a situation, the expression of the IL-10 and TNF- genes increases, promoting the survival of glial cell neurons, blocking the effects of pro-inflammatory cytokines and promoting the expression of cell survival signals [2,3].For the treatment of tension headache, a special treatment complex of osteopathic techniques has been developed, aimed at eliminating muscle tension and restoring normal blood circulation in the neck, shoulder girdle, chest, and head, which effectively reduces the mechanical causes of pain.However, for a full understanding and optimization of treatment, it is advisable to move on to monitoring biochemical processes, in particular, monitoring the level of cytokines (IL-6, TNF-, IL-10), which reflect the degree and can adjust additional methods to enhance the effect of osteopathy.