FEATURES OF ARTERIAL HYPERTENSION CLINICAL COURSE IN PATIENTS WITH STABLE ISCHEMIC HEART DISEASE AND IRRITABLE BOWEL SYNDROME

treatment, 7 days after the normalization of urine passage, the level continued to rise, increasing by 26% compared to day 1.MCP-1 in the urine of patients at the beginning of treatment was 257.6 pg/ml, which exceeded the normal values by more than 40%.During the medication therapy and normalization of urodynamics, the concentration of MCP-1 in urine continued to increase, reaching 297.6 pg/ml on day 7. IGF-1, which is synthesized by lymphocytes and macrophages and stimulates collagen synthesis by fibroblasts, significantly exceeded the normal range on the first day of treatment, with a value of 14.3 pg/ml.It is important to note that the increase in this marker was less pronounced compared to TGF- and MCP-1.Thus, TGF-, MCP-1, and to a lesser extent, IGF-1 in blood and urine serve as markers for the development of kidney fibrosis in acute upper urinary tract obstruction.Their dynamic changes in serum and urine reflect the progression of kidney damage and may provide valuable information about the mechanisms of the disease and potential therapeutic approaches.