Different action of glucocorticoid receptor in adipose tissue remodelling to modulate energy homeostasis by chronic restraint stress
This study provides novel insights into the contrasting thermogenic phenotypes of BAT and WAT under emaciation and highlights the critical role of GRs in adipose tissue remodelling during CRS and its potential as a therapeutic target. Addressing GR-mediated changes in adipose tissues may help alleviate BAT dysfunction in cachexia and promote WAT browning, enhancing metabolic stress resistance.
Authors
- Yinghua Luo
- Yaqian Mao (ORCID: https://orcid.org/0000-0002-1836-7834)
- Gang Chen (ORCID: https://orcid.org/0000-0001-6067-6959)
- Junping Wen
- Qinyu Liu (ORCID: https://orcid.org/0000-0003-3925-1352)
Institutions
- Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1186/s12944-025-02539-0
- Citations
- 3
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- National Natural Science Foundation of China
- National Clinical Key Specialty Project Foundation