Electrochemical Determination of Atazanavir Using Electrodes Modified with Cobalt Metal–Organic Framework/Carbon Nanotube Composites

Maximizing effectiveness and minimizing side effects are always at the front line of medical treatment for chronic diseases, such as human immunodeficiency virus infection/acquired immunodeficiency syndrome (HIV/AIDS). Herein, an innovative electrochemical method has been developed for monitoring Atazanavir (ATZ) levels, a common HIV/AIDS antiviral, in patients’ biofluids. The fabricated sensor is constructed from electrochemically synthesized cobalt metal–organic frameworks (Co-MOFs) with polyhedron morphology, which are uniformly decorated onto carbon nanotube (CNT)-coated glassy carbon electrodes to create sensitive sensors due to their high surface area, rapid electrode kinetics, low overvoltage, and reasonable electrical conductance. Fast response time, great selectivity, reproducibility, accurate measurements across a wide range of concentrations (0.5–60 μM) with low detection limit (0.16 μM), and exceptional sensitivity (0.32 μA μM–1), which works in near-physiological pH conditions, make the fabricated electrodes promising for the detection of ATZ levels. Moreover, the fabricated sensing platforms are remarkably able to measure ATZ in human blood serum and pharmaceutical samples without any sample pretreatment. This breakthrough sensing platform opens up a promising research area for HIV treatment and electrochemical monitoring.