TP53 gene mutation in lymphoepithelioma‑like carcinoma of the breast with thyroid cancer: A case report

Globally, breast cancer is the most common malignancy among women and thyroid cancer is also one of the common cancer types among women. Patients with breast cancer exhibit a higher incidence of thyroid cancer than that noted in the general population. The exact mechanism of multiple tumors remains elusive. In the present study, the case of a patient with multiple tumors harboring gene mutation is reported. Specifically, a patient with lymphoepithelioma-like carcinoma of the breast (LELC-B) and thyroid cancer is described. It was hypothesized that the short interval between the onset of these two types of malignant tumor may be related to the TP53 gene mutation status of the patient. To date, a specific relationship between gene mutations and multiple tumors is yet to be determined. Therefore, additional studies are required to address this topic.