Exploring the interaction effects of subclinical hypothyroidism and major depressive disorder on brain networks
Our study reveals significant FC changes in SHypo-MDD patients, particularly in the PVN, VSMN, and DSMN, suggesting compensatory mechanisms that mitigate cognitive deficits and highlighting the need for integrated management of SHypo and MDD to improve cognitive outcomes.
Authors
- Haowen Zou
- Qing Lü (ORCID: https://orcid.org/0000-0001-7717-391X)
- Yishan Du (ORCID: https://orcid.org/0000-0001-8273-8081)
- Hao Sun (ORCID: https://orcid.org/0000-0003-2001-7056)
- Zhijian Yao (ORCID: https://orcid.org/0000-0002-4573-1697)
- Xumiao Wang
- Zhilu Chen (ORCID: https://orcid.org/0000-0002-7165-7996)
- Shuai Zhao (ORCID: https://orcid.org/0009-0009-1967-8675)
- Xiaomei Liu (ORCID: https://orcid.org/0000-0003-4526-4985)
- Xiaoqin Wang (ORCID: https://orcid.org/0000-0003-0715-7177)
- Xia Yi (ORCID: https://orcid.org/0000-0003-4427-5738)
- Rui Yan (ORCID: https://orcid.org/0009-0000-5681-5370)
- Hao Tang (ORCID: https://orcid.org/0000-0002-6197-0874)
- Jin-dan Wu (ORCID: https://orcid.org/0000-0001-8814-5869)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Anhui Medical University (CN)
- Nanjing Brain Hospital (CN)
- Huai'an City Fourth People's Hospital (CN)
- Anhui Mental Health Center (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s12916-025-03995-2
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00