Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells
Combining computational modeling and single-cell sequencing, our study reveals that the performance of mitochondrial lineage tracing is highly dependent on the extent of clonal expansion, which thus should be considered when applying mitochondrial lineage tracing.
Authors
- Da Zhou
- Yuying Cheng (ORCID: https://orcid.org/0009-0000-6797-0413)
- Jin Xu (ORCID: https://orcid.org/0000-0003-0586-6084)
- Xin Wang (ORCID: https://orcid.org/0000-0001-7440-1075)
- Zheng Hu (ORCID: https://orcid.org/0000-0003-1552-0060)
- Qing Ma
- Wen‐Zhao Zhong (ORCID: https://orcid.org/0000-0002-8917-8635)
- Kun Wang (ORCID: https://orcid.org/0009-0009-6503-4678)
- Chengqi Zhang (ORCID: https://orcid.org/0000-0001-5715-7154)
- Weixing Zhang (ORCID: https://orcid.org/0009-0009-7723-3631)
- Zhongjie Tang (ORCID: https://orcid.org/0009-0003-0534-5411)
- Hao Zhang
Institutions
- Sun Yat-sen University (CN)
- Henan University (CN)
- Xiamen University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Genome biology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1186/s13059-025-03540-7
- Citations
- 4
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Basic and Applied Basic Research Foundation of Guangdong Province