Association of diabetic nephropathy with lipid metabolism: a Mendelian randomization study
TG is a risk factor for DN and UACR; HDL-C is protective for both; ApoA1 protects against DN; and ApoB is a risk factor for UACR. To further explore the underlying mechanisms between TG, HDL-C, ApoA1, ApoB, and their associations with DN and UACR, and to provide reference for the selection of lipid management and treatment strategies for clinical DN patients. This study demonstrated that causal relationships between TG, HDL-C, and ApoA1 with DN and between TG, HDL-C, and ApoB with the UACR.
Authors
- Pengfei Xie (ORCID: https://orcid.org/0000-0001-8018-1371)
- Linhua Zhao (ORCID: https://orcid.org/0000-0002-0362-7365)
- Lili Zhang (ORCID: https://orcid.org/0000-0002-9877-5810)
- Yi Huang (ORCID: https://orcid.org/0000-0003-0115-7694)
- Weinan Xie
- Zhaobo Wang (ORCID: https://orcid.org/0000-0002-8949-1373)
- Haoyu Yang (ORCID: https://orcid.org/0000-0002-0644-6930)
- Ling Zhou (ORCID: https://orcid.org/0000-0002-2664-9583)
- Wei Yu (ORCID: https://orcid.org/0000-0002-9672-3849)
- Rumeng Tang
- Ziwei Guo
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Guang’anmen Hospital (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s13098-025-01641-8
- Citations
- 6
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 8.13
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality
- National Key Research and Development Program of China